"Non-reactive" means negative. Case closed.
The problems you’re having don’t sound at all like drug side effects; they sound like symptoms that should be evaluated by your doctor. If someone comes to me with fever, sweats, headaches, and insomnia, a drug reaction would be very low on my list of causes.
Between your undetectable viral load and his being on top, the risk of transmission is infinitessimaly small. You shouldn’t be worried.
Do you have to? No
Should you? Yes. Doctors can take better care of you if they know your medical history and what medications you’re taking.
Tybost is a booster; Vitetka is an integrase inhibitor. You can use either Tybost or Norvir (but not both) to boost Prezista, Reyataz, and other protease inhibitors. Vitetka is not a booster; it needs boosting. You can use Tybost to boost Vitetka too.
The guidelines say that you should “consider” shingles vaccine if you’re over 60 and have a CD4 count over 200. I’d go a little further and would recommend it.
Yes, you’ll have that option right away. If you’re having side effects from Norvir, switching to Tybost might help. However, the tolerability of Tybost has been similar to that of Norvir in clinical trials—its main advantage is that it will be coformulated with other drugs.
See continuation below.
You could have a drug fever from Bactrim. The timing of the fever with respect to the dose doesn’t really matter. One of the common features of drug fever is that you tend to feel “inappropriately well” despite having a fever, and that your heart rate doesn’t increase as much as it would if you had a fever due to infection. (With infection, you should have a heart rate of at least 110 with a fever to 102; with drug fever it’s often lower.)
The easiest way to find out whether Bactrim is the cause is to stop taking it for a while. If you have a drug fever, the fever will go away quickly. If it doesn’t, then you need to be evaluated for other causes of fever.
A short interruption of your PCP prophylaxis shouldn’t be dangerous since you’re now on antiretroviral therapy. However, there are alternative forms of prophylaxis if you can’t take Bactrim, including dapsone and atovaquone. Talk to your doctor about this.
It is a strange name, I agree, but my guess is that Tybost will be like Emtriva. Emtriva is the brand name for emtricitabine (FTC), a widely used drug, but almost always taken as part of a combination pill (Truvada, Atripla, Complera, or Stribild). Few people take emtricitabine in the form of Emtriva. Similarly, cobicistat will be used mostly in Stribild and in pills that combine it with Prezista or Reyataz. leaving few people on Tybost. If you really hate the name, you can take some comfort in that.